Dataset Information

Integrated proteomics and phosphoproteomics revealed druggable kinases in neoadjuvant chemotherapy resistant tongue cancer

ABSTRACT: Tongue squamous cell carcinoma is characterised by poor prognosis and high metastatic events. Patients with unresectable tumors are benefiting from neoadjuvant chemotherapy (NACT) which surgical resection, and controls distant metastasis, and locoregional recurrence. However, resistance to NACT limit the success of the treatment regimen. In this study, we investigated the altered proteome and phosphoproteome of NACT resistant and sensitive cohort using Mass spectrometry-based proteomics. We carried out proteomic as well as phosphoproteomic analysis of treatment naïve tongue cancer patients whose response to NACT is recorded. Proteomic analysis revealed distinct protein expression between the responders and non-responders. The Phosphoproteomic analysis revealed kinases and the pathways associated with NACT resistance in tongue cancer.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Tongue Cancer Cell

DISEASE(S): Tongue Cancer

SUBMITTER: Irene A George

LAB HEAD: Dr. Prashant Kumar

PROVIDER: PXD037356 | Pride | 2023-03-11

REPOSITORIES: pride

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			Action	DRS
	Oral_Cavity_Phospho_Irene_F10_R1.raw	Raw
	Oral_Cavity_Phospho_Irene_F10_R2.raw	Raw
	Oral_Cavity_Phospho_Irene_F11_R1.raw	Raw
	Oral_Cavity_Phospho_Irene_F11_R2.raw	Raw
	Oral_Cavity_Phospho_Irene_F12_R1.raw	Raw

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Integrated proteomics and phosphoproteomics revealed druggable kinases in neoadjuvant chemotherapy resistant tongue cancer.

George Irene A IA Sathe Gajanan G Ghose Vivek V Chougule Anuradha A Chandrani Pratik P Patil Vijay V Noronha Vanita V Venkataramanan R R Limaye Sewanti S Pandey Akhilesh A Prabhash Kumar K Kumar Prashant P

Frontiers in cell and developmental biology 20221028

Tongue squamous cell carcinoma is an aggressive oral cancer with a high incidence of metastasis and poor prognosis. Most of the oral cavity cancer patients present in clinics with locally advanced unresectable tumors. Neoadjuvant treatment is beneficial for these individuals as it reduces the tumor size aiding complete resection. However, patients develop therapy resistance to the drug regimen. In this study, we explored the differential expression of proteins and altered phosphorylation in the ...[more]

PMID: 36393868

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