Proteomics

Dataset Information

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Proteomic analysis of mitochondria from Huntington's Disease patient iPSC-derived neurons


ABSTRACT: Huntington's disease is caused by an expanded CAG repeat in the huntingtin gene, yeilding a Huntingtin protein with an expanded polyglutamine tract. Patient-derived induced pluripotent stem cells (iPSCs) can help understand disease; however, defining pathological biomarkers in challanging. Here we used LC-MS/MS to determine differences in mitochondrial proteome between iPSC-derived neurons from healthy donors and Huntington's disease patients.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Ranen Aviner  

LAB HEAD: Ranen Aviner

PROVIDER: PXD037526 | Pride | 2023-02-10

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
P20210603-03_WT_1.raw Raw
P20210603-04_WT_2.raw Raw
P20210603-05_WT_3.raw Raw
P20210603-11_HD_1.raw Raw
P20210603-12_HD_2.raw Raw
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Publications


Huntington's disease (HD) is caused by an expanded CAG repeat in the huntingtin gene, yielding a Huntingtin protein with an expanded polyglutamine tract. While experiments with patient-derived induced pluripotent stem cells (iPSCs) can help understand disease, defining pathological biomarkers remains challenging. Here, we used cryogenic electron tomography to visualize neurites in HD patient iPSC-derived neurons with varying CAG repeats, and primary cortical neurons from BACHD, deltaN17-BACHD, a  ...[more]

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