Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Ranen Aviner
LAB HEAD: Ranen Aviner
PROVIDER: PXD037526 | Pride | 2023-02-10
REPOSITORIES: Pride
Action | DRS | |||
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P20210603-03_WT_1.raw | Raw | |||
P20210603-04_WT_2.raw | Raw | |||
P20210603-05_WT_3.raw | Raw | |||
P20210603-11_HD_1.raw | Raw | |||
P20210603-12_HD_2.raw | Raw |
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Nature communications 20230208 1
Huntington's disease (HD) is caused by an expanded CAG repeat in the huntingtin gene, yielding a Huntingtin protein with an expanded polyglutamine tract. While experiments with patient-derived induced pluripotent stem cells (iPSCs) can help understand disease, defining pathological biomarkers remains challenging. Here, we used cryogenic electron tomography to visualize neurites in HD patient iPSC-derived neurons with varying CAG repeats, and primary cortical neurons from BACHD, deltaN17-BACHD, a ...[more]