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Multiomics Approach to Profiling Development of the Spermatogonial Stem Cell Niche Focused on Sertoli cell Maturation

ABSTRACT: Spermatogonial stem cells are the foundation of spermatogenesis and as such can serve as a tool for the treatment of infertility in prepubertal cancer survivors. Spermatogonial stem cells are unique as they develop from primordial germ cells (PGCs), which colonize the developing tubules as immature SSC precursors. It has been controversial, when SSCs are maturing to an adult-like stem cell and recent research has found that prepubertal SSCs are actually metabolically distinct from adult SSCs until puberty. Sertoli cells picture a major part of the SSC niche and undergo drastic changes with puberty and polarize to compartmentalize the seminiferous epithelium with formation of tight junctions to a tight basal part where SSCs reside and an apical part with more differentiated stages of spermatogenesis. In the study were mapping the progression of Sertoli cells maturation events to the metabolic changes SSCs undergo during prepubertal development.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)

TISSUE(S): Sertoli Cell

SUBMITTER: Luiz Gustavo de Almeida

LAB HEAD: Antoine Dufour

PROVIDER: PXD037764 | Pride | 2023-02-24

REPOSITORIES: Pride

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			Action	DRS
	Phospho_Anna_July28_2021.zip	Other
	S11958_SC_11_81_Phospho_210616.raw	Raw
	S11959_SC_12_82_Phospho_210616.raw	Raw
	S11960_SC_13_83_Phospho_210616.raw	Raw
	S11961_SC_14_84_Phospho_210616.raw	Raw

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