Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Suspension Culture, T Cell
DISEASE(S): Acute Leukemia
SUBMITTER: Jose Luis Marin-Rubio
LAB HEAD: María Villa-Morales
PROVIDER: PXD037858 | Pride | 2023-03-11
REPOSITORIES: Pride
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20220322_JLMR_JK_DIA_IP-FADD1.raw | Raw | |||
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20220322_JLMR_JK_DIA_IP-FADD4.raw | Raw | |||
20220322_JLMR_JK_DIA_IP-NEG1.raw | Raw |
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International journal of molecular sciences 20221202 23
A reduction in <i>FADD</i> levels has been reported in precursor T-cell neoplasms and other tumor types. Such reduction would impact on the ability of tumor cells to undergo apoptosis and has been associated with poor clinical outcomes. However, FADD is also known to participate in non-apoptotic functions, but these mechanisms are not well-understood. Linking FADD expression to the severity of precursor T-cell neoplasms could indicate its use as a prognostic marker and may open new avenues for t ...[more]