Dataset Information

A dual role for FADD in human T-cell lymphoblastic neo-plasms

ABSTRACT: In this study, we set out to get insight into the clinical implications of FADD expres-sion in T-cell lymphoblastic neoplasms, and to explore the landscape of deregulated cell signaling events in human T-cell lymphoblastic neoplasms, taking FADD expression as the defining variable.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Suspension Culture, T Cell

DISEASE(S): Acute Leukemia

SUBMITTER: Jose Luis Marin-Rubio

LAB HEAD: María Villa-Morales

PROVIDER: PXD037858 | Pride | 2023-03-11

REPOSITORIES: pride

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Dataset's files

Source:

			Action	DRS
	20220322_JLMR_JK_DIA_IP-FADD1.raw	Raw
	20220322_JLMR_JK_DIA_IP-FADD2.raw	Raw
	20220322_JLMR_JK_DIA_IP-FADD3.raw	Raw
	20220322_JLMR_JK_DIA_IP-FADD4.raw	Raw
	20220322_JLMR_JK_DIA_IP-NEG1.raw	Raw

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Publications

A Dual Role for FADD in Human Precursor T-Cell Neoplasms.

Marín-Rubio José Luis JL Vela-Martín Laura L Gudgeon Jack J Pérez-Gómez Eduardo E Sidgwick Frances R FR Trost Matthias M Cunningham Debbie L DL Santos Javier J Fernández-Piqueras José J Villa-Morales María M

International journal of molecular sciences 20221202 23

A reduction in <i>FADD</i> levels has been reported in precursor T-cell neoplasms and other tumor types. Such reduction would impact on the ability of tumor cells to undergo apoptosis and has been associated with poor clinical outcomes. However, FADD is also known to participate in non-apoptotic functions, but these mechanisms are not well-understood. Linking FADD expression to the severity of precursor T-cell neoplasms could indicate its use as a prognostic marker and may open new avenues for t ...[more]

PMID: 36499482

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