Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF-X
ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)
TISSUE(S): Lung
DISEASE(S): Diabetes Mellitus
SUBMITTER: Bachuki Shashikadze
LAB HEAD: Thomas Fröhlich
PROVIDER: PXD038014 | Pride | 2024-07-01
REPOSITORIES: Pride
Shashikadze Bachuki B Flenkenthaler Florian F Kemter Elisabeth E Franzmeier Sophie S Stöckl Jan B JB Haid Mark M Riols Fabien F Rothe Michael M Pichl Lisa L Renner Simone S Blutke Andreas A Wolf Eckhard E Fröhlich Thomas T
Disease models & mechanisms 20240723 7
Growing evidence shows that the lung is an organ prone to injury by diabetes mellitus. However, the molecular mechanisms of these pulmonary complications have not yet been characterized comprehensively. To systematically study the effects of insulin deficiency and hyperglycaemia on the lung, we combined proteomics and lipidomics with quantitative histomorphological analyses to compare lung tissue samples from a clinically relevant pig model for mutant INS gene-induced diabetes of youth (MIDY) wi ...[more]