Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos, Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): B Cell
DISEASE(S): Cardiovascular System Disease
SUBMITTER: Vas Narayanaswami
LAB HEAD: Vas Narayanaswami
PROVIDER: PXD038105 | Pride | 2024-08-09
REPOSITORIES: Pride
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Abeer Muhammad I MI Abdulhasan Abbas A Haguar Zahraa Z Narayanaswami Vasanthy V
The FEBS journal 20230208 11
High levels of 4-hydroxynonenal (HNE), arising from lipid peroxidation, and HNE-modified proteins have been identified in postmortem brains of ageing and Alzheimer's disease (AD) patients. The goal of this study is to understand the effect of HNE modification on the structure and function of recombinant apolipoprotein E3 (apoE3) and apolipoprotein E4 (apoE4), which play a critical role in brain cholesterol homeostasis. The two isoforms differ in a single amino acid at position 112: Cys in apoE3 ...[more]