Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Trypanosoma Brucei
TISSUE(S): Permanent Cell Line Cell, Cell Culture
DISEASE(S): Trypanosomiasis
SUBMITTER: Martin Zoltner
LAB HEAD: Martin Zoltner
PROVIDER: PXD038550 | Pride | 2023-06-14
REPOSITORIES: Pride
Action | DRS | |||
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BioID_ALPH1.txt.rar | Txt | |||
BioID_ALPH1_OE_1.raw | Raw | |||
BioID_ALPH1_OE_2.raw | Raw | |||
BioID_ALPH1_OE_3.raw | Raw | |||
BioID_ALPH1_cat_1.raw | Raw |
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Nucleic acids research 20230801 14
Removal of the mRNA 5' cap primes transcripts for degradation and is central for regulating gene expression in eukaryotes. The canonical decapping enzyme Dcp2 is stringently controlled by assembly into a dynamic multi-protein complex together with the 5'-3'exoribonuclease Xrn1. Kinetoplastida lack Dcp2 orthologues but instead rely on the ApaH-like phosphatase ALPH1 for decapping. ALPH1 is composed of a catalytic domain flanked by C- and N-terminal extensions. We show that T. brucei ALPH1 is dime ...[more]