Proteomics

Dataset Information

0

Identification of the intracellular protein targets of a clickable half-sandwich iridium complex by chemical proteomics


ABSTRACT: This study aims at identifying intracellular proteins that are targeted by half-sandwich Ir(III) organometallic drugs. We recently demonstrated that half-sandwich Ir(III) complexes are able to form adducts with the side chain of certain amino-acids (Cys and His for example) and with cellular proteins in vivo. We use an azido-substituted half-sandwich iridium complex to fish out protein adducts, using click chemistry and ethynyl-agarose beads

INSTRUMENT(S): Orbitrap Eclipse

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Kidney

SUBMITTER: Vanessa Masson  

LAB HEAD: Damarys Loew

PROVIDER: PXD038711 | Pride | 2024-04-11

REPOSITORIES: pride

Dataset's files

Source:
Action DRS
Design_PRIDE-Joelle.xlsx Xlsx
E0012FD_2.msf Msf
E0012FD_2.raw Raw
E0013FD_2.msf Msf
E0013FD_2.raw Raw
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