Identification of the intracellular protein targets of a clickable half-sandwich iridium complex by chemical proteomics
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ABSTRACT: This study aims at identifying intracellular proteins that are targeted by half-sandwich Ir(III) organometallic drugs. We recently demonstrated that half-sandwich Ir(III) complexes are able to form adducts with the side chain of certain amino-acids (Cys and His for example) and with cellular proteins in vivo. We use an azido-substituted half-sandwich iridium complex to fish out protein adducts, using click chemistry and ethynyl-agarose beads
INSTRUMENT(S): Orbitrap Eclipse
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Kidney
SUBMITTER: Vanessa Masson
LAB HEAD: Damarys Loew
PROVIDER: PXD038711 | Pride | 2024-04-11
REPOSITORIES: pride
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