Dataset Information

Identification of proteins in the plasma associated with heifer infertility

ABSTRACT: We carried out an experiment to test the hypothesis that differences in protein abundance due to fertility fitness would be shared between heifers of different breeds. We produced proteome data from the plasma collected from 22 heifers (purebred Angus heifers (n=12), purebred Holstein (n=10) heifers). The protein Alpha-ketoglutarate-dependent dioxygenase FTO was more abundant in the plasma collected from Fertile heifers relative to Sub-fertile counterparts (FDR < 0.05).

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Bos Taurus (bovine)

TISSUE(S): Blood Cell, Blood Plasma

DISEASE(S): Infertility

SUBMITTER: Keith Ray

LAB HEAD: Fernando Biase

PROVIDER: PXD038756 | Pride | 2023-10-24

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	220915_Bovine_BS10_01.raw	Raw
	220915_Bovine_BS10_02.raw	Raw
	220915_Bovine_BS1_01-_1_.msf	Msf
	220915_Bovine_BS1_01-_1_.msfView	Msf
	220915_Bovine_BS1_01-_1_.mzML	Mzml

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Publications

A multi-omics analysis identifies molecular features associated with fertility in heifers (Bos taurus).

Marrella Mackenzie A MA Biase Fernando H FH

Scientific reports 20230804 1

Infertility or subfertility is a critical barrier to sustainable cattle production, including in heifers. The development of heifers that do not produce a calf within an optimum window of time is a critical factor for the profitability and sustainability of the cattle industry. In parallel, heifers are an excellent biomedical model for understanding the underlying etiology of infertility because well-nourished heifers can still be infertile, mostly because of inherent physiological and genetic c ...[more]

PMID: 37542054

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