Label-free quantitative proteomic analyses of mouse astrocytes provides insight into the host response mechanism at different developmental stages of Toxoplasma gondii
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Cell Culture
SUBMITTER: 
Huanhuan Xie
LAB HEAD: Kun Yin
PROVIDER: PXD038919 | Pride | 2023-08-25
REPOSITORIES: Pride
Dataset's files
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|---|---|---|---|---|
| FA670LQ_C8RH1_1.raw | Raw | |||
| FA670LQ_C8RH1_2.raw | Raw | |||
| FA670LQ_C8RH1_3.raw | Raw | |||
| FA670LQ_C8_1.raw | Raw | |||
| FA670LQ_C8_2.raw | Raw |
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Project description:Toxoplasmosis is a zoonotic disease caused by a ubiquitous protozoan parasite called Toxoplasma gondii, which can
infect all mammal and bird species throughout the world. seroprevalence varies widely between countries. Studies
have estimated that between 7-34% of people in the UK have been infected with T. gondii. The vast majority of these
people will not have noticed any symptoms, however about 10% of people develop a mild to moderate self limiting
flu-like illness. Following the acute active stage of the infection the parasite persists in the body in the form of cysts,
particularly in heart and skeletal muscle and nervous system tissues, for many years, and usually for life. In
immunocompetent persons these cysts do not pose a health risk. We will use RNA-seq to quantify the transcriptional
response of macrophages to T gondii infection.
This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/
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