Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Laura Herring
LAB HEAD: Lee Graves
PROVIDER: PXD038990 | Pride | 2023-05-10
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 64 |
Fennell Emily M J EMJ Aponte-Collazo Lucas J LJ Pathmasiri Wimal W Rushing Blake R BR Barker Natalie K NK Partridge Megan C MC Li Yuan-Yuan YY White Cody A CA Greer Yoshimi E YE Herring Laura E LE Lipkowitz Stanley S Sumner Susan C J SCJ Iwanowicz Edwin J EJ Graves Lee M LM
Frontiers in pharmacology 20230331
ClpP activators ONC201 and related small molecules (TR compounds, Madera Therapeutics), have demonstrated significant anti-cancer potential in <i>vitro</i> and <i>in vivo</i> studies, including clinical trials for refractory solid tumors. Though progress has been made in identifying specific phenotypic outcomes following ClpP activation, the exact mechanism by which ClpP activation leads to broad anti-cancer activity has yet to be fully elucidated. In this study, we utilized a multi-omics approa ...[more]