Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: yang wen
LAB HEAD: Wang Lei
PROVIDER: PXD039060 | Pride | 2023-10-24
REPOSITORIES: pride
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proteomic_of_RCC2_IP_with_infection.raw | Raw |
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Cheng Zhihui Z Zheng Yangyang Y Yang Wen W Sun Hongmin H Zhou Fangyu F Huang Chuangjie C Zhang Shuwen S Song Yingying Y Liang Qi'an Q Yang Nan N Li Meifang M Liu Bin B Feng Lu L Wang Lei L
Proceedings of the National Academy of Sciences of the United States of America 20230921 39
The human blood-brain barrier (BBB) comprises a single layer of brain microvascular endothelial cells (HBMECs) protecting the brain from bloodborne pathogens. Meningitis is among the most serious diseases, but the mechanisms by which major meningitis-causing bacterial pathogens cross the BBB to reach the brain remain poorly understood. We found that <i>Streptococcus pneumoniae</i>, group B <i>Streptococcus</i>, and neonatal meningitis <i>Escherichia coli</i> commonly exploit a unique vesicle fus ...[more]