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Patient-derived podocyte spheroids reveals new insights into the etiopathogenesis of Alport Syndrome

ABSTRACT: Alport syndrome (AS) is a rare disease characterized by defective glomerular basement membranes, caused by mutations in COL4A3, COL4A4 and COL4A5, which synthesize collagen type IV. Patients present with progressive proteinuria, hematuria and podocyte loss. There is currently no cure for AS, and this is mainly due to its complex and variable pathogenesis, as well as the lack of models that can faithfully mimic the human phenotype.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Embryonic Stem Cell

DISEASE(S): Alport Syndrome

SUBMITTER: Sadr Shaheed

LAB HEAD: Dr Sadr ul Shaheed

PROVIDER: PXD039214 | Pride | 2023-02-21

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	01042021-CING-1DLCMS-AS1-AS3-LT-day-14-podo-Combined-MS22_PSMs.txt	Txt
	01042021-CING-1DLCMS-AS1-AS3-LT-day-14-podo-Combined-MS22_PeptideGroups.txt	Txt
	01042021-CING-1DLCMS-AS1-AS3-LT-day-14-podo-Combined-MS22_Proteins.txt	Txt
	16032021-10122020-AS1-day-14-podo-1DLCMS-Alport-1-5-Inj01.raw	Raw
	16032021-10122020-AS1-day-14-podo-1DLCMS-Alport-1-5-Inj02.raw	Raw

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