Dataset Information

Proteomics of Pulmonary alveolar microlithiasis nodules

ABSTRACT: The proteomics aspect of this project was simply to catalog the protein content in microlith nodule isolated from a Pulmonary alveolar microlithiasis patient or from a mouse model of the disease

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Lung

DISEASE(S): Pulmonary Alveolar Microlithiasis

SUBMITTER: ken greis

LAB HEAD: Kenneth D. Greis

PROVIDER: PXD039280 | Pride | 2023-03-11

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	Data011817_02_Output_Group_file_for_Table_3_mus_musculus.group	Other
	Data011817_02_Peak_file_for_Table_3_mus_musculus.mgf	Mgf
	Data011817_02_Raw_file_for_Table_3_mus_musculus.mzML	Mzml
	Data111317_04_Output_Groups_file_for_Table_2_homo_sapiens.group	Other
	Data111317_04_Peak_file_for_Table_2_homo_sapiens.mgf	Mgf

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Publications

Insights into pulmonary phosphate homeostasis and osteoclastogenesis emerge from the study of pulmonary alveolar microlithiasis.

Uehara Yasuaki Y Tanaka Yusuke Y Zhao Shuyang S Nikolaidis Nikolaos M NM Pitstick Lori B LB Wu Huixing H Yu Jane J JJ Zhang Erik E Hasegawa Yoshihiro Y Noel John G JG Gardner Jason C JC Kopras Elizabeth J EJ Haffey Wendy D WD Greis Kenneth D KD Guo Jinbang J Woods Jason C JC Wikenheiser-Brokamp Kathryn A KA Kyle Jennifer E JE Ansong Charles C Teitelbaum Steven L SL Inoue Yoshikazu Y Altinişik Göksel G Xu Yan Y McCormack Francis X FX

Nature communications 20230302 1

Pulmonary alveolar microlithiasis is an autosomal recessive lung disease caused by a deficiency in the pulmonary epithelial Npt2b sodium-phosphate co-transporter that results in accumulation of phosphate and formation of hydroxyapatite microliths in the alveolar space. The single cell transcriptomic analysis of a pulmonary alveolar microlithiasis lung explant showing a robust osteoclast gene signature in alveolar monocytes and the finding that calcium phosphate microliths contain a rich protein ...[more]

PMID: 36864068

Dataset Information

Proteomics of Pulmonary alveolar microlithiasis nodules

Dataset's files

Publications

Insights into pulmonary phosphate homeostasis and osteoclastogenesis emerge from the study of pulmonary alveolar microlithiasis.

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