Proteomics

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Immunization with lytic polysaccharide monooxygenase CbpD induces protective immunity against Pseudomonas aeruginosa pneumonia

ABSTRACT: Bacterial lytic polysaccharide monooxygenases (LPMOs) are understudied in the context of infection disease. We demonstrated that Pseudomonas aeruginosa LPMO CbpD is a virulence determinant in pneumonia. Moreover, Mice immunized with CbpD generate robust antibody responses that provide protection against lethal lung infection

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Lung

SUBMITTER: Jack-Ansgar Bruun  

LAB HEAD: Victor Nizet

PROVIDER: PXD039298 | Pride | 2023-07-26

REPOSITORIES: Pride

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210510_FAskarian_NMBU_TMT10_GR1_A1.raw Raw
210510_FAskarian_NMBU_TMT10_GR1_A10.raw Raw
210510_FAskarian_NMBU_TMT10_GR1_A2.raw Raw
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Publications

<i>Pseudomonas aeruginosa</i> (PA) CbpD belongs to the lytic polysaccharide monooxygenases (LPMOs), a family of enzymes that cleave chitin or related polysaccharides. Here, we demonstrate a virulence role of CbpD in PA pneumonia linked to impairment of host complement function and opsonophagocytic clearance. Following intratracheal challenge, a PA ΔCbpD mutant was more easily cleared and produced less mortality than the wild-type parent strain. The x-ray crystal structure of the CbpD LPMO domain  ...[more]

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