Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Skeletal Muscle Fiber, Skeletal Muscle Cell Line, Skeletal Muscle Myoblast In Skeletal Muscle
DISEASE(S): Disease Free
SUBMITTER: Brenda Janice Sanchez
LAB HEAD: Imed E. Gallouzi
PROVIDER: PXD039388 | Pride | 2024-05-24
REPOSITORIES: Pride
Items per page: 1 - 5 of 7 |
Nucleic acids research 20240401 7
Poly(ADP-ribosylation) (PARylation) is a post-translational modification mediated by a subset of ADP-ribosyl transferases (ARTs). Although PARylation-inhibition based therapies are considered as an avenue to combat debilitating diseases such as cancer and myopathies, the role of this modification in physiological processes such as cell differentiation remains unclear. Here, we show that Tankyrase1 (TNKS1), a PARylating ART, plays a major role in myogenesis, a vital process known to drive muscle ...[more]