Proteomics

Dataset Information

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Proteomic analysis of the mandibular glands from the Chinese crocodile lizard, Shinisaurus crocodilurus – another venomous lizard?


ABSTRACT: Based on its phylogenetic relationship to monitor lizards (Varanidae), Gila monsters (Heloderma spp.), and the earless monitor Lanthanotus borneesis, the Chinese crocodile lizard, Shinisaurus crocodilurus, has been assigned to the Toxicofera clade, which comprises venomous reptiles. However, no data about composition and biological activities of its oral secretion have been reported. In the present study, a proteomic analysis of the mandibular gland of S. crocodilurus and, for comparison, of the herbivorous Solomon Island skink Corucia zebrata, was performed. Scanning electron microscopy (SEM) of the teeth from S. crocodilurus revealed a sharp ridge on the anterior surface, but no grooves, whereas those of C. zebrata possess a flattened crown with a pointed cusp. Proteomic analysis of their gland extracts provided no evidence of venom-derived peptides or proteins, strongly supporting the non-venomous character of these lizards.

INSTRUMENT(S): Synapt MS, Q Exactive HF

ORGANISM(S): Corucia Shinisaurus Crocodilurus

TISSUE(S): Submandibular Gland

SUBMITTER: Davinia Pla  

LAB HEAD: Juan José Calvete Chornet

PROVIDER: PXD039424 | Pride | 2023-03-11

REPOSITORIES: pride

Dataset's files

Source:
Action DRS
Bottom_up-Table_Corucia.xlsx Xlsx
Bottom_up-Tables_Shinisaurus.xlsx Xlsx
Corucia_raw.rar Other
Gl_10_CID.pkl Other
Gl_11_CID.pkl Other
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Publications

Proteomic analysis of the mandibular glands from the Chinese crocodile lizard, Shinisaurus crocodilurus - Another venomous lizard?

Calvete Juan J JJ   Lomonte Bruno B   Lorente Carolina C   Pla Davinia D   Zollweg Michael M   Mebs Dietrich D  

Toxicon : official journal of the International Society on Toxinology 20230201


Based on its phylogenetic relationship to monitor lizards (Varanidae), Gila monsters (Heloderma spp.), and the earless monitor Lanthanotus borneesis, the Chinese crocodile lizard, Shinisaurus crocodilurus, has been assigned to the Toxicofera clade, which comprises venomous reptiles. However, no data about composition and biological activities of its oral secretion have been reported. In the present study, a proteomic analysis of the mandibular gland of S. crocodilurus and, for comparison, of the  ...[more]

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