Dataset Information

Neonatal rat cardiomyocytes LC-MS/MS

ABSTRACT: NRCMs were treated with ISO (10 μM) in the presence or absence of FGF18 (50 ng/ml) for 48 h. Protein bands at ~60 kDa were excised from the SDS-PAGE gels for LC-MS/MS analysis

INSTRUMENT(S): LTQ

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Heart

DISEASE(S): Cardiovascular System Disease

SUBMITTER: xu wang

LAB HEAD: Xu Wang

PROVIDER: PXD039587 | Pride | 2023-03-11

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	20220715NRCMs_3_3006.msf	Msf
	20220715NRCMs_3_3006.raw	Raw
	rat_0904.fasta	Fasta

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Publications

Fibroblast growth factor 18 alleviates stress-induced pathological cardiac hypertrophy in male mice.

Chen Gen G An Ning N Shen Jingling J Chen Huinan H Chen Yunjie Y Sun Jia J Hu Zhicheng Z Qiu Junhui J Jin Cheng C He Shengqu S Mei Lin L Sui Yanru Y Li Wanqian W Chen Peng P Guan Xueqiang X Chu Maoping M Wang Yang Y Jin Litai L Kim Kwonseop K Li Xiaokun X Cong Weitao W Wang Xu X

Nature communications 20230304 1

Fibroblast growth factor-18 (FGF18) has diverse organ development and damage repair roles. However, its role in cardiac homeostasis following hypertrophic stimulation remains unknown. Here we investigate the regulation and function of the FGF18 in pressure overload (PO)-induced pathological cardiac hypertrophy. FGF18 heterozygous (Fgf18<sup>+/-</sup>) and inducible cardiomyocyte-specific FGF18 knockout (Fgf18-CKO) male mice exposed to transverse aortic constriction (TAC) demonstrate exacerbated ...[more]

PMID: 36871047

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