Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell
SUBMITTER: Frank Stein
LAB HEAD: Dr. Doris Hoeglinger
PROVIDER: PXD039780 | Pride | 2023-02-07
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 11 |
Altuzar Janathan J Notbohm Judith J Stein Frank F Haberkant Per P Hempelmann Pia P Heybrock Saskia S Worsch Jutta J Saftig Paul P Höglinger Doris D
Proceedings of the National Academy of Sciences of the United States of America 20230309 11
Lysosomes are catabolic organelles involved in macromolecular digestion, and their dysfunction is associated with pathologies ranging from lysosomal storage disorders to common neurodegenerative diseases, many of which have lipid accumulation phenotypes. The mechanism of lipid efflux from lysosomes is well understood for cholesterol, while the export of other lipids, particularly sphingosine, is less well studied. To overcome this knowledge gap, we have developed functionalized sphingosine and c ...[more]