Trypanosomatid extracellular vesicles as potential immunogens in Chagas disease

ABSTRACT: Extracellular vesicles (EVs) from parasite protozoa can induce efficient immunity, which makes them useful for probable next-generation vaccines, more specifically against Trypanosoma cruzi infection. Howevver, the mechanisms involved in the protective responses have not been fully elucidated. To investigate the potential use of trypanosomatid EVs as immunogens against Chagas disease we tested the effect of EVs stimulation from Trypanosoma rangeli and Phytomonas serpens compared to T. cruzi response in vitro and in vivo, besides performing a proteomics evaluation of the EVs.Overall, our results pointed out that EVs of T. cruzi-correlated parasites have antigenic potential. Despite minor effects in the modulation of antigen presentation cells surface receptors and in in vitro T. cruzi infection, T. rangeli and P. serpens EVs can contribute to reducing T. cruzi infectivity in Balb/c mice.

INSTRUMENT(S): LTQ Orbitrap XL ETD

ORGANISM(S): Trypanosoma Cruzi Dm28c Phytomonas Serpens Trypanosoma Rangeli

SUBMITTER: Michel Batista  

LAB HEAD: Pryscilla Fanini Wowk

PROVIDER: PXD040019 | Pride | 2025-01-21

REPOSITORIES: pride