Dataset Information

Differential activation of NRF2 signaling pathway in renal cell carcinoma cells

ABSTRACT: Comprehensive comparative proteomic analysis of Caki-1, a classical ccRCC cell line versusCaki-2 cells using tandem mass tag reagents based approach for identification and quantitation of proteins in the two cell lines by liquid chromatography tandem mass spectrometry (LC/MS/MS).

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Kidney

DISEASE(S): Kidney Cancer

SUBMITTER: Julius Nyalwidhe

LAB HEAD: Julius O Nyalwidhe

PROVIDER: PXD040083 | Pride | 2023-07-20

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	CAKI-Cells_TMT.msf	Msf
	CAKI-Cells_TMT.tsv.xlsx	Xlsx
	CAKI-Cells_TMT_Fraction_1.raw	Raw
	CAKI-Cells_TMT_Fraction_2.raw	Raw
	CAKI-Cells_TMT_Fraction_3.raw	Raw

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Publications

Differential Activation of NRF2 Signaling Pathway in Renal-Cell Carcinoma Caki Cell Lines.

Hitefield Naomi L NL Mackay Stephen S Hays Lauren E LE Chen Shimin S Oduor Ian O IO Troyer Dean A DA Nyalwidhe Julius O JO

Biomedicines 20230324 4

Renal-cell carcinoma (RCC) is a heterogeneous disease consisting of several subtypes based on specific genomic profiles and histological and clinical characteristics. The subtype with the highest prevalence is clear-cell RCC (ccRCC), next is papillary RCC (pRCC), and then chromophobe RCC (chRCC). The ccRCC cell lines are further subdivided into prognostic expression-based subtypes ccA or ccB. This heterogeneity necessitates the development, availability, and utilization of cell line models with ...[more]

PMID: 37189628

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