Proteomics

Dataset Information

0

Genetically modified ID8 cells to study the role of GBP1 in ovarian cancer


ABSTRACT: Genetically modified ovarian cancer cells were used to study the role of GBP1. Proteomics-based thermal stability assay (CETSA) was performed on GBP1 knockdown and overexpressing ID8 ovarian cancer cells. Shotgun proteomics was also performed on these cells.

INSTRUMENT(S): Orbitrap Eclipse, LTQ Orbitrap Elite

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cell Culture

DISEASE(S): Malignant Neoplasm Of Ovary

SUBMITTER: Sharon Pitteri  

LAB HEAD: Sharon Pitteri

PROVIDER: PXD040444 | Pride | 2024-01-26

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
Combined_msms_TMT_Sample_03_050418.txt Txt
Dhanir_TMT_Sample_03_050418_01.raw Raw
Dhanir_TMT_Sample_03_050418_02.raw Raw
Dhanir_TMT_Sample_03_050418_03.raw Raw
ID8_KD_RTS_01.pdResult Other
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Publications

Guanylate-binding protein 1 modulates proteasomal machinery in ovarian cancer.

Tailor Dhanir D   Garcia-Marques Fernando Jose FJ   Bermudez Abel A   Pitteri Sharon J SJ   Malhotra Sanjay V SV  

iScience 20231024 11


Guanylate-binding protein 1 (GBP1) is known as an interferon-γ-induced GTPase. Here, we used genetically modified ovarian cancer (OC) cells to study the role of GBP1. The data generated show that GBP1 inhibition constrains the clonogenic potential of cancer cells. <i>In vivo</i> studies revealed that GBP1 overexpression in tumors promotes tumor progression and reduces median survival, whereas GBP1 inhibition delayed tumor progression with longer median survival. We employed proteomics-based ther  ...[more]

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