Proteomics

Dataset Information

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The proteomic response of C. elegans to two protective Pseudomonas symbionts


ABSTRACT: The two C. elegans natural microbiota isolates Pseudomonas lurida MYb11 and Pseudomonas fluorescens MYb115 protect the host against pathogens through distinct mechanisms. While P. lurida produces an antimicrobial compound and directly inhibits pathogen growth, P. fluorescens MYb115 protects the host without affecting pathogen growth. It is unknown how these two protective microbes affect host biological processes. We used a proteomics approach to elucidate the C. elegans response to MYb11 and MYb115. We found that both Pseudomonas isolates increase vitellogenin protein production in adult day 1 animals, which confirms previous findings on the effect of microbiota on C. elegans reproductive timing. Moreover, the C. elegans responses to MYb11 and MYb115 exhibit common signatures with the response to other vitamin B12-producing bacteria, emphasizing the importance of vitamin B12 in C. elegans-microbe metabolic interactions.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Caenorhabditis Elegans

TISSUE(S): Whole Body

SUBMITTER: Andreas Tholey  

LAB HEAD: Andreas Tholey

PROVIDER: PXD040520 | Pride | 2024-05-24

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
DDA_HCD-KK01_OK5E9_MYB11.raw Raw
DDA_HCD-KK04_OK8E9_OP50.raw Raw
DDA_HCD-KK08_OK9E9_MYB11.raw Raw
DDA_HCD-KK09_OK8E9_MYB11.raw Raw
DDA_HCD-KK10_OK9E9_OP50.raw Raw
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Publications

The <i>Caenorhabditis elegans</i> proteome response to two protective <i>Pseudomonas</i> symbionts.

Pees Barbara B   Peters Lena L   Treitz Christian C   Hamerich Inga K IK   Kissoyan Kohar A B KAB   Tholey Andreas A   Dierking Katja K  

mBio 20240227 4


The <i>Caenorhabditis elegans</i> natural microbiota isolates <i>Pseudomonas lurida</i> MYb11 and <i>Pseudomonas fluorescens</i> MYb115 protect the host against pathogens through distinct mechanisms. While <i>P. lurida</i> produces an antimicrobial compound and directly inhibits pathogen growth, <i>P. fluorescens</i> MYb115 protects the host without affecting pathogen growth. It is unknown how these two protective microbes affect host biological processes. We used a proteomics approach to elucid  ...[more]

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