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Mouse Kidney LC-MS/MS with HRP-Ism1

ABSTRACT: Potential interacting proteins of Isthmin-1 in E11.5 intact tissue during early kidney development.

INSTRUMENT(S): autoflex

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Kidney

SUBMITTER: Ge GAO

LAB HEAD: Zhongjun ZHOU

PROVIDER: PXD040642 | Pride | 2023-05-11

REPOSITORIES: pride

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			Action	DRS
	10624_mqpar.xml	Xml
	210525-7832-raw.txt	Txt
	210610-8070_raw.txt	Txt
	211130-10624_raw.txt	Txt
	7832_mqpar.xml	Xml

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Publications

Isthmin-1 (Ism1) modulates renal branching morphogenesis and mesenchyme condensation during early kidney development.

Gao Ge G Li Xiaoping X Jiang Zhixin Z Osorio Liliana L Tang Ying Lam YL Yu Xueqing X Jin Guoxiang G Zhou Zhongjun Z

Nature communications 20230425 1

The outgrowth of epithelial bud followed by reiterated bifurcations during renal development is driven by the ligand-receptor interactions between the epithelium and the surrounding mesenchyme. Here, by exploring ligand-receptor interactions in E10.5 and E11.5 kidneys by single cell RNA-seq, we find that Isthmin1 (Ism1), a secreted protein, resembles Gdnf expression and modulates kidney branching morphogenesis. Mice deficient for Ism1 exhibit defective ureteric bud bifurcation and impaired metan ...[more]

PMID: 37185772

Publication: 1/2

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