Dataset Information

Osteosarcoma cells-derived secretome induce pre-metastatic changes in the lung microenvironment that support lung metastasis formation

ABSTRACT: To investigate the molecular and cellular alterations occurring in the lung tissue during the pre-metastatic niche formation in osteosarcoma, we used two two experimental mouse models and a multi-omics approach.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Culture Fluid

SUBMITTER: Ana Sofia Ribeiro

LAB HEAD: Célia Gomes

PROVIDER: PXD040814 | Pride | 2024-01-26

REPOSITORIES: pride

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Publications

Unveiling the role of osteosarcoma-derived secretome in premetastatic lung remodelling.

Almeida Sara F F SFF Santos Liliana L Sampaio-Ribeiro Gabriela G Ferreira Hugo R S HRS Lima Nuno N Caetano Rui R Abreu Mónica M Zuzarte Mónica M Ribeiro Ana Sofia AS Paiva Artur A Martins-Marques Tânia T Teixeira Paulo P Almeida Rui R Casanova José Manuel JM Girão Henrique H Abrunhosa Antero J AJ Gomes Célia M CM

Journal of experimental & clinical cancer research : CR 20231130 1

<h4>Background</h4>Lung metastasis is the most adverse clinical factor and remains the leading cause of osteosarcoma-related death. Deciphering the mechanisms driving metastatic spread is crucial for finding open therapeutic windows for successful organ-specific interventions that may halt or prevent lung metastasis.<h4>Methods</h4>We employed a mouse premetastatic lung-based multi-omics integrative approach combined with clinical features to uncover the specific changes that precede lung metast ...[more]

PMID: 38031171

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