Proteomics

Dataset Information

0

Mitochondrial interactome quantitation with dead-end peptides in failing murine heart


ABSTRACT: Dead-end peptide quantitation for improved interpretation of corresponding cross-link abundance differences

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart, Fibroblast

DISEASE(S): Myocardial Ischemia

SUBMITTER: Andrew Keller  

LAB HEAD: Dr James Edward Bruce

PROVIDER: PXD040864 | Pride | 2024-10-17

REPOSITORIES: Pride

Dataset's files

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Publications

Integrated Analysis of Cross-Links and Dead-End Peptides for Enhanced Interpretation of Quantitative XL-MS.

Keller Andrew A   Tang Xiaoting X   Bruce James E JE  

Journal of proteome research 20230808 9


Chemical cross-linking with mass spectrometry provides low-resolution structural information on proteins in cells and tissues. Combined with quantitation, it can identify changes in the interactome between samples, for example, control and drug-treated cells or young and old mice. A difference can originate from protein conformational changes that alter the solvent-accessible distance separating the cross-linked residues. Alternatively, a difference can result from conformational changes localiz  ...[more]

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