Dataset Information

Brain Proteomic Atlas of Alcohol Use Disorder in Adult Males

ABSTRACT: Alcohol use disorder (AUD) affects transcriptomic, epigenetic and proteomic expression in several organs including the brain. Multi-omic analyses of the brain from individuals with AUD to date lack a comprehensive analysis of protein alterations in the multiple brain regions that underlie neuroadaptations occurring in AUD. We performed quantitative proteomic analysis using liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis of human post-mortem tissue from brain regions that play a key role in the development and maintenance of AUD: amygdala (AMG), hippocampus (HIPP), hypothalamus (HYP), nucleus accumbens (NAc), prefrontal cortex (PFC) and ventral tegmental area (VTA). Brain tissues analyzed were from individuals with AUD (n = 11) and matched controls (n = 16).

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

SUBMITTER: Thomas Conrads

LAB HEAD: Thomas P Conrads

PROVIDER: PXD040884 | Pride | 2023-10-24

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	A44520_UL296296.PDF	Pdf
	Brain_AUD_Sample_Reference_File.xlsx	Xlsx
	Human_SP_120117.fasta	Fasta
	NIAAA_TMTpro_QEHFX1_020521_12_01.raw	Raw
	NIAAA_TMTpro_QEHFX1_020521_12_02.raw	Raw

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Brain proteomic atlas of alcohol use disorder in adult males.

Teng Pang-Ning PN Barakat Waleed W Tran Sophie M SM Tran Zoe M ZM Bateman Nicholas W NW Conrads Kelly A KA Wilson Katlin N KN Oliver Julie J Gist Glenn G Hood Brian L BL Zhou Ming M Maxwell G Larry GL Leggio Lorenzo L Conrads Thomas P TP Lee Mary R MR

Translational psychiatry 20231013 1

Alcohol use disorder (AUD) affects transcriptomic, epigenetic and proteomic expression in several organs, including the brain. There has not been a comprehensive analysis of altered protein abundance focusing on the multiple brain regions that undergo neuroadaptations occurring in AUD. We performed a quantitative proteomic analysis using a liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis of human postmortem tissue from brain regions that play key roles in the development and ma ...[more]

PMID: 37833300

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