Proteomics

Dataset Information

0

Human Pancreatic Ductal Adenocarcinoma (PDAC), LC-MS/MS

ABSTRACT: The aim of the study was to characterize a common molecular mechanism for paclitaxel resistance in Patu-T and Suit-2.028 PDAC cell lines. Despite the ATP-binding cassette (ABC) trasnsporters were already shown to be involved in various chemo-resistant forms of cancers but not in PDAC, the most likely impact of ABCB1 overexpression in PDAC cell models was taken into account in this dataset.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Diploid Cell

DISEASE(S): Pancreatic Ductal Adenocarcinoma

SUBMITTER: Francesco Finamore  

LAB HEAD: Elisa Giovannetti

PROVIDER: PXD040930 | Pride | 2024-01-26

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
OR1_20211117_ES803Arev2_B20137969_35C_LTrap_NN_SUIT_WT_Gregori_1.mgf Mgf
OR1_20211117_ES803Arev2_B20137969_35C_LTrap_NN_SUIT_WT_Gregori_1.raw Raw
OR1_20211122_ES803Arev2_B20137969_35C_LTrap_NN_PATU_PR_Gregori_13.mgf Mgf
OR1_20211122_ES803Arev2_B20137969_35C_LTrap_NN_PATU_PR_Gregori_13.raw Raw
OR1_20211123_ES803Arev2_B20137969_35C_LTrap_NN_PATU_GR_Gregori_18.mgf Mgf
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Publications

ABCB1 overexpression through locus amplification represents an actionable target to combat paclitaxel resistance in pancreatic cancer cells.

Bergonzini Cecilia C   Gregori Alessandro A   Hagens Tessa M S TMS   van der Noord Vera E VE   van de Water Bob B   Zweemer Annelien J M AJM   Coban Bircan B   Capula Mjriam M   Mantini Giulia G   Botto Asia A   Finamore Francesco F   Garajova Ingrid I   McDonnell Liam A LA   Schmidt Thomas T   Giovannetti Elisa E   Danen Erik H J EHJ  

Journal of experimental & clinical cancer research : CR 20240102 1

<h4>Background</h4>Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest types of cancer and the chemotherapies such as gemcitabine/nab-paclitaxel are confronted with intrinsic or acquired resistance. The aim of this study was to investigate mechanisms underlying paclitaxel resistance in PDAC and explore strategies to overcome it.<h4>Methods</h4>Three paclitaxel (PR) and gemcitabine resistant (GR) PDAC models were established. Transcriptomics and proteomics were used to identify conser  ...[more]

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