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Proteomic analysis of hippocampal tissue in mice in acute temporal lobe epilepsy

ABSTRACT: A total of 5762.0 proteins were identified in this study, of which 4891.0 proteins contained quantitative information. If a 1.2-fold differential expression change threshold is used and a statistical test t-test p-value < 0.05 is used as the significance threshold, then among the proteins quantified, we found that 95 proteins were up-regulated and 45 proteins were down-regulated in the treatvscontrol comparison group.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Cong Huang

LAB HEAD: Jiahang Sun

PROVIDER: PXD040967 | Pride | 2023-05-10

REPOSITORIES: Pride

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	F9032TQ_01.raw	Raw
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	F9032TQ_03.raw	Raw
	F9032TQ_04.raw	Raw
	F9032TQ_05.raw	Raw

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Combined transcriptomics and proteomics forecast analysis for potential biomarker in the acute phase of temporal lobe epilepsy.

Huang Cong C You Zhipeng Z He Yijie Y Li Jiran J Liu Yang Y Peng Chunyan C Liu Zhixiong Z Liu Xingan X Sun Jiahang J

Frontiers in neuroscience 20230330

<h4>Background</h4>Temporal lobe epilepsy (TLE) is a common chronic episodic illness of the nervous system. However, the precise mechanisms of dysfunction and diagnostic biomarkers in the acute phase of TLE are uncertain and hard to diagnose. Thus, we intended to qualify potential biomarkers in the acute phase of TLE for clinical diagnostics and therapeutic purposes.<h4>Methods</h4>An intra-hippocampal injection of kainic acid was used to induce an epileptic model in mice. First, with a TMT/iTRA ...[more]

PMID: 37065920

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