Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 480
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Liver
SUBMITTER: Felix Boel Pedersen
LAB HEAD: Blagoy Blagoev
PROVIDER: PXD041168 | Pride | 2023-09-07
REPOSITORIES: pride
Items per page: 5 1 - 5 of 42 |
Correia Catarina Mendes CM Præstholm Stine Marie SM Havelund Jesper Foged JF Pedersen Felix Boel FB Siersbæk Majken Storm MS Ebbesen Morten Frendø MF Gerhart-Hines Zach Z Heeren Joerg J Brewer Jonathan J Larsen Steen S Blagoev Blagoy B Færgeman Nils Joakim NJ Grøntved Lars L
Endocrinology 20230801 10
Hepatic lipid metabolism is highly dynamic, and disruption of several circadian transcriptional regulators results in hepatic steatosis. This includes genetic disruption of the glucocorticoid receptor (GR) as the liver develops. To address the functional role of GR in the adult liver, we used an acute hepatocyte-specific GR knockout model to study temporal hepatic lipid metabolism governed by GR at several preprandial and postprandial circadian timepoints. Lipidomics analysis revealed significan ...[more]