Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 480
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Fiona Pachl
LAB HEAD: Andrew Zhang
PROVIDER: PXD041225 | Pride | 2024-09-23
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 50 |
Taylor Jonathan D JD Barrett Nathalie N Martinez Cuesta Sergio S Cassidy Katelyn K Pachl Fiona F Dodgson James J Patel Radhika R Eriksson Tuula M TM Riley Aidan A Burrell Matthew M Bauer Christin C Rees D Gareth DG Cimbro Raffaello R Zhang Andrew X AX Minter Ralph R RR Hunt James J Legg Sandrine S
Communications biology 20240919 1
Proteins can be targeted for degradation by engineering biomolecules that direct them to the eukaryotic ubiquitination machinery. For instance, the fusion of an E3 ubiquitin ligase to a suitable target binding domain creates a 'biological Proteolysis-Targeting Chimera' (bioPROTAC). Here we employ an analogous approach where the target protein is recruited directly to a human E2 ubiquitin-conjugating enzyme via an attached target binding domain. Through rational design and screening we develop E2 ...[more]