Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): B Cell, Blood
SUBMITTER: lina wang
LAB HEAD: Li Wang
PROVIDER: PXD041227 | Pride | 2024-05-24
REPOSITORIES: Pride
Wang Lina L Yang Shushu S Zhu Gaohui G Li Jie J Meng Gang G Chen Xiaoling X Zhang Mengjun M Wang Shufeng S Li Xiangqian X Pan Yu Y Huang Yi Y Wang Li L Wu Yuzhang Y
Cellular & molecular immunology 20240430 6
Autoreactive CD8<sup>+</sup> T cells play a key role in type 1 diabetes (T1D), but the antigen spectrum that activates autoreactive CD8<sup>+</sup> T cells remains unclear. Endoplasmic reticulum stress (ERS) has been implicated in β-cell autoantigen generation. Here, we analyzed the major histocompatibility complex class I (MHC-I)-associated immunopeptidome (MIP) of islet β-cells under steady and ERS conditions and found that ERS reshaped the MIP of β-cells and promoted the MHC-I presentation of ...[more]