Convergence of distinct RNA-silencing pathways on GW182/Tnrc6
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ABSTRACT: The RNA-binding protein Trim71/Lin41 is a phylogenetically conserved developmental regulator that functions in mammalian stem cell reprogramming, brain development and cancer. Trim71 recognizes target mRNAs through hairpin motifs and silences them through molecular mechanisms that await identification. Deposited data are mass spectrometry data from immunoprecipitation experiments with endogenously tagged Tnrc6a. Experiments are carried out in mouse embryonic stem cells (mESCs) in the presence and absence of RNase A.
INSTRUMENT(S): Orbitrap Eclipse
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Cell Culture, Embryonic Stem Cell
SUBMITTER: Daniel Hess
LAB HEAD: Helge Grosshans
PROVIDER: PXD041242 | Pride | 2023-07-04
REPOSITORIES: Pride
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