Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Marc Timmers
LAB HEAD: Marc Timmers
PROVIDER: PXD041254 | Pride | 2024-01-28
REPOSITORIES: Pride
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Fotouhi Omid O Nizamuddin Sheikh S Falk Stephanie S Schilling Oliver O Knüchel-Clarke Ruth R Biniossek Martin L ML Timmers H T Marc HTM
Cancers 20230608 12
The UTX/KDM6A histone H3K27 demethylase plays an important role in development and is frequently mutated in cancers such as urothelial cancer. Despite many studies on UTX proteins, variations in mRNA splicing have been overlooked. Using Nanopore sequencing, we present a comprehensive analysis of UTX/KDM6A splicing events in human cell lines and in tissue samples from bladder cancer cases and normal epithelia. We found that the central region of UTX mRNAs encoded by exons 12 to 17 undergoes exten ...[more]