Dataset Information

Characterization of the interactome of receptor tyrosine kinase proline rich motifs

ABSTRACT: Here we explore the interactome of the proline-rich motif regions of non-activated receptor tyrosine kinases by affinity purification mass spectrometry.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Antonio Calabrese

LAB HEAD: John Ladbury

PROVIDER: PXD041383 | Pride | 2024-10-01

REPOSITORIES: Pride

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			Action	DRS
	0112018_Arndt_IP_HP1_1.raw	Raw
	0112018_Arndt_IP_HP1_2.raw	Raw
	0112018_Arndt_IP_HP2_1.raw	Raw
	0112018_Arndt_IP_HP2_2.raw	Raw
	0112018_Arndt_IP_HP3_1.raw	Raw

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Affinity purification mass spectrometry characterisation of the interactome of receptor tyrosine kinase proline-rich motifs in cancer.

Jones Christopher M CM Rohwedder Arndt A Suen Kin Man KM Mohajerani Safoura Zahed SZ Calabrese Antonio N AN Knipp Sabine S Bedford Mark T MT Ladbury John E JE

Heliyon 20240731 15

Receptor tyrosine kinase (RTK) overexpression is linked to the development and progression of multiple cancers. RTKs are classically considered to initiate cytoplasmic signalling pathways via ligand-induced tyrosine phosphorylation, however recent evidence points to a second tier of signalling contingent on interactions mediated by the proline-rich motif (PRM) regions of non-activated RTKs. The presence of PRMs on the C-termini of >40 % of all RTKs and the abundance of PRM-binding proteins encod ...[more]

PMID: 39165974

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