Ontology highlight
ABSTRACT:
INSTRUMENT(S): timsTOF Pro
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Breast Cancer
SUBMITTER: Chiara guerrera
LAB HEAD: Ida Chiara Guerrera
PROVIDER: PXD041545 | Pride | 2023-12-20
REPOSITORIES: Pride
Items per page: 1 - 5 of 23 |
Cell death & disease 20231115 11
Ferroptosis constitutes a promising therapeutic strategy against cancer by efficiently targeting the highly tumorigenic and treatment-resistant cancer stem cells (CSCs). We previously showed that the lysosomal iron-targeting drug Salinomycin (Sal) was able to eliminate CSCs by triggering ferroptosis. Here, in a well-established breast CSCs model (human mammary epithelial HMLER CD24<sup>low</sup>/CD44<sup>high</sup>), we identified that pharmacological inhibition of the mechanistic target of rapa ...[more]