PROTEOMIC PROFILE OF THE URINE OF BOTHROPIC ENVENOMING VICTIMS’ WHO DEVELOPED ACUTE KIDNEY INJURY

ABSTRACT: Snakebite is a serious public health problem and is classified as a neglected tropical disease that affects approximately 2.7 million people worldwide and results in more than 138.000 deaths per year, the vast majority in tropical and subtropical countries. Brazil is among the six countries with the highest number of snakebite poisonings, 111,932 cases are reported annually, 86.7% of which are botropic accidents. Amazonas has high rates of snakebite cases, registering approximately 9,174 annual cases across the state. Bothrops atrox, whose venom triggers local and systemic effects in its victims, is responsible for about 80-90% of cases in the region. The effect of botropic venom can cause everything from local manifestations to systemic changes, with acute renal failure being one of the most important complications resulting from these poisonings with high rates of morbidity and mortality. Proteomic analysis has the potential to visualize molecular changes and can be a powerful tool in the prior identification of differential proteins associated with toxicity and severity or progression of a given disease. Urine is a less complex sample when compared to other biofluids and can be a useful tool in the identification of kidney disease biomarkers. Thus, this study aimed to characterize the protein profile in urine samples of patient’s victims of a botropic accident with clinical outcome of acute renal failure.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Urine

SUBMITTER: Priscila Aquino  

LAB HEAD: Priscila Aquino

PROVIDER: PXD041548 | Pride | 2024-03-18

REPOSITORIES: Pride