Dataset Information

The Hidden Culprit of Visceral Fat: Dysfunctional Subcutaneous Adipose Tissue – Adipose tissue proteomics

ABSTRACT: To investigate the proteomic profiles of paired subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) samples, as well as their correlations with clinical traits in severely obese patients, and to identify potential serum protein markers associated with tissue expression or metabolic states.

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Adipose Tissue

DISEASE(S): Obesity

SUBMITTER: David Potesil

LAB HEAD: Zbynek Zdrahal

PROVIDER: PXD041721 | Pride | 2023-10-16

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	3388_Hruska_QEx1_lib_90min-IS_top20_IT50_13_01.raw	Raw
	3388_Hruska_QEx1_lib_90min-IS_top20_IT50_14_01.raw	Raw
	3388_Hruska_QEx1_lib_90min-IS_top20_IT50_15_01.raw	Raw
	3388_Hruska_QEx1_lib_90min-IS_top20_IT50_16_01.raw	Raw
	3388_Hruska_QEx1_lib_90min-IS_top20_IT50_17_01.raw	Raw

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Publications

Unraveling adipose tissue proteomic landscapes in severe obesity: insights into metabolic complications and potential biomarkers.

Hruska Pavel P Kucera Jan J Kuruczova Daniela D Buzga Marek M Pekar Matej M Holeczy Pavol P Potesil David D Zdrahal Zbynek Z Bienertova-Vasku Julie J

American journal of physiology. Endocrinology and metabolism 20231004 5

In this study, we aimed to comprehensively characterize the proteomic landscapes of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) in patients with severe obesity, to establish their associations with clinical characteristics, and to identify potential serum protein biomarkers indicative of tissue-specific alterations or metabolic states. We conducted a cross-sectional analysis of 32 patients with severe obesity (16 males and 16 females) of Central European descent who under ...[more]

PMID: 37792298

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