Dataset Information

Proteome analysis of claws, clawless toe tips and back skin of Xenopus tropicalis

ABSTRACT: The aim of the study was to determine the protein composition of cornified claws of the western clawed frog (Xenopus tropicalis) in comparison to clawless toe tips and back skin. Cornified claws develop on toes I, II, III of the hind limbs, which we refer to as hind limb inner (HI) toes. Toes IV, V of the hind limbs, here referred to as hind limb outer (HO) toes lack claws. Proteins were prepared from HI toe tips including claws, HO toe tips and back skin (BSK) of frogs each (F1, F2, F3) and subjected to proteomic analysis.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Xenopus Tropicalis

TISSUE(S): Keratinocyte, Skin, Fibroblast

SUBMITTER: Attila Placido Sachslehner

LAB HEAD: Univ.-Prof. DDr.

PROVIDER: PXD041765 | Pride | 2024-02-20

REPOSITORIES: pride

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Publications

Evolutionary origin of Hoxc13-dependent skin appendages in amphibians.

Carron Marjolein M Sachslehner Attila Placido AP Cicekdal Munevver Burcu MB Bruggeman Inge I Demuynck Suzan S Golabi Bahar B De Baere Elfride E Declercq Wim W Tschachler Erwin E Vleminckx Kris K Eckhart Leopold L

Nature communications 20240318 1

Cornified skin appendages, such as hair and nails, are major evolutionary innovations of terrestrial vertebrates. Human hair and nails consist largely of special intermediate filament proteins, known as hair keratins, which are expressed under the control of the transcription factor Hoxc13. Here, we show that the cornified claws of Xenopus frogs contain homologs of hair keratins and the genes encoding these keratins are flanked by promoters in which binding sites of Hoxc13 are conserved. Further ...[more]

PMID: 38499530

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			Action	DRS
	2302013bXtv2F1HIplus.raw	Raw
	2302014bXtv2F1HO.raw	Raw
	2302015bXtv2F1BSK.raw	Raw
	2302016bXtv2F2HIplus.raw	Raw
	2302017bXtv2F2HO.raw	Raw