Dataset Information
Identification of AF9-associated proteins by IP and mass spectrometry
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Erythrocyte, Cell Culture
DISEASE(S): Acute Leukemia
SUBMITTER: 
Ruoyu Zhao
LAB HEAD: Ruoyu Zhao
PROVIDER: PXD042008 | Pride | 2024-10-17
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| P20170600115_6.mgf | Mgf | |||
| P20170600115_6.raw | Raw | |||
| P20170600115_7.mgf | Mgf | |||
| P20170600115_7.raw | Raw |
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Publications
MLL-AF9 regulates transcriptional initiation in mixed lineage leukemic cells.
The Journal of biological chemistry 20240711 8
Mixed lineage leukemia-fusion proteins (MLL-FPs) are believed to maintain gene activation and induce MLL through aberrantly stimulating transcriptional elongation, but the underlying mechanisms are incompletely understood. Here, we show that both MLL1 and AF9, one of the major fusion partners of MLL1, mainly occupy promoters and distal intergenic regions, exhibiting chromatin occupancy patterns resembling that of RNA polymerase II in HEL, a human erythroleukemia cell line without MLL1 rearrangem ...[more]
