Proteomics

Dataset Information

0

Human nucleus pulposus cell LC-MS/MS


ABSTRACT: To identify PPP1CA interactome in human nucleus pulposus cell

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Primary Cell

SUBMITTER: Huaizhen Liang  

LAB HEAD: Cao Yang

PROVIDER: PXD042397 | Pride | 2023-10-24

REPOSITORIES: pride

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Publications

Lysine methylation of PPP1CA by the methyltransferase SUV39H2 disrupts TFEB-dependent autophagy and promotes intervertebral disc degeneration.

Liang Huaizhen H   Luo Rongjin R   Li Gaocai G   Zhang Weifeng W   Zhu Dingchao D   Wu Di D   Zhou Xingyu X   Tong Bide B   Wang Bingjin B   Feng Xiaobo X   Wang Kun K   Song Yu Y   Yang Cao C  

Cell death and differentiation 20230821 9


Impaired transcription factor EB (TFEB) function and deficient autophagy activity have been shown to aggravate intervertebral disc (IVD) degeneration (IDD), yet the underlying mechanisms remain less clear. Protein posttranslational modifications (PTMs) are critical for determining TFEB trafficking and transcriptional activity. Here, we demonstrate that TFEB activity is controlled by protein methylation in degenerated nucleus pulposus cells (NPCs), even though TFEB itself is incapable of undergoi  ...[more]

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