Human nasal epithelial cell, Influenza virus, iTRAQ
Ontology highlight
ABSTRACT: Few studies have examined the local surface remodeling of primary human nasal epithelial cells (HNECs) during viral infection. Hence, the full range of upregulated adhesion molecules during respiratory viral infections that facilitate bacterial attachment and entry remain unknown. Accordingly, the current study provides a comprehensive view of HNEC responses to influenza virus pH1N1 infection, via global proteome profiling of uninfected (Mock, n = 4) and influenza-infected (Virus-only, n = 4) HNECs with isobaric tags using relative and absolute quantitation (iTRAQ) technique. A total of 3583 proteins were detected, 89 of which were significantly increased (52 proteins) or decreased (37 proteins) in the virus-infected HNECs compared to mock-infected controls (p < 0.05).
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Primary Cell, Epithelial Cell
DISEASE(S): Influenza
SUBMITTER: Youn Wook Chung
LAB HEAD: Ji-Hwan Ryu
PROVIDER: PXD042618 | Pride | 2024-05-08
REPOSITORIES: Pride
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