Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 480
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Cell Culture
DISEASE(S): Non-small Cell Lung Carcinoma
SUBMITTER: Marcel Schilling
LAB HEAD: Prof. Ursula Klingmüller
PROVIDER: PXD042728 | Pride | 2024-04-11
REPOSITORIES: Pride
Items per page: 1 - 5 of 45 |
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20240319
Precision oncology has revolutionized the treatment of ALK-positive lung cancer with targeted therapies. However, an unmet clinical need still to address is the treatment of refractory tumors that contain drug-induced resistant mutations in the driver oncogene or exhibit resistance through the activation of diverse mechanisms. In this study, we established mouse tumor-derived cell models representing the two most prevalent EML4-ALK variants in human lung adenocarcinomas and characterized their p ...[more]