Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Rattus Norvegicus (rat)
TISSUE(S): Retina
DISEASE(S): Glaucoma
SUBMITTER: Laszlo Prokai
LAB HEAD: Laszlo Prokai
PROVIDER: PXD042729 | Pride | 2023-10-24
REPOSITORIES: Pride
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International journal of molecular sciences 20230809 16
Elevated intraocular pressure is considered a major cause of glaucomatous retinal neurodegeneration. To facilitate a better understanding of the underlying molecular processes and mechanisms, we report a study focusing on alterations of the retina proteome by induced ocular hypertension in a rat model of the disease. Glaucomatous processes were modeled through sclerosing the aqueous outflow routes of the eyes by hypertonic saline injections into an episcleral vein. Mass spectrometry-based quanti ...[more]