Dataset Information

Next-generation proteomics of brain extracellular vesicles in schizophrenia provide new clues on the altered molecular connectome

ABSTRACT: Extracellular vesicles (EVs) are tiny membranous structures capable of mediating intercellular communication. In the brain, the role(s) of EVs have been extensively studied in the context of neurological diseases, but their potential implications in the neuropathology underlying human mental disorders remain largely unexplored. Here, we investigated the potential role(s) of brain EVs in schizophrenia (SZ) by analyzing these vesicles from the three post-mortem anatomical brain regions: prefrontal cortex (PFC), hippocampus (HC) and caudate (CAU), using next-generation discovery-driven proteomics. Our results indicate that EVs from SZ-affected brains present region-specific proteins associated with abnormal GABAergic and glutamatergic transmission, as well as alterations in proteins involved in synaptic decay, abnormal brain immunity, neuronal structural imbalances and impaired cell homeostasis. Our findings also provide the first evidence that molecular exchange networks are potentially active and mediated by EVs in cognitively healthy brains. These EV-mediated networks were partially reversed and largely disrupted in brains affected by SZ.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

DISEASE(S): Schizophrenia

SUBMITTER: Cristina Lorca

LAB HEAD: Aida Serra Maqueda

PROVIDER: PXD042732 | Pride | 2024-05-24

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	210205_201008A_Gallart_CTRL1_CAU_S1-B1_1_589.d.7z	Other
	210205_201008A_Gallart_CTRL1_HC_S1-B2_1_590.d.7z	Other
	210205_201008A_Gallart_CTRL1_pFc_S1-B3_1_591.d.7z	Other
	210205_201008A_Gallart_CTRL2_CAV_S1-B4_1_592.d.7z	Other
	210205_201008A_Gallart_CTRL2_HC_S1-B5_1_593.d.7z	Other

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Publications

Next-Generation Proteomics of Brain Extracellular Vesicles in Schizophrenia Provide New Clues on the Altered Molecular Connectome.

Lorca Cristina C Fernández-Rhodes María M Sánchez Milán Jose Antonio JA Mulet María M Elortza Félix F Ramos-Miguel Alfredo A Callado Luis F LF Meana J Javier JJ Mur Maria M Batalla Iolanda I Vilella Elisabet E Serra Aida A Gallart-Palau Xavier X

Biomedicines 20240108 1

Extracellular vesicles (EVs) are tiny membranous structures that mediate intercellular communication. The role(s) of these vesicles have been widely investigated in the context of neurological diseases; however, their potential implications in the neuropathology subjacent to human psychiatric disorders remain mostly unknown. Here, by using next-generation discovery-driven proteomics, we investigate the potential role(s) of brain EVs (bEVs) in schizophrenia (SZ) by analyzing these vesicles from t ...[more]

PMID: 38255234

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