Dataset Information

Stepwise emergence of the neuronal gene expression program in early animal evolution

ABSTRACT: The assembly of the neuronal and other major cell type programs occurred early in animal evolution. We can reconstruct this process by studying non-bilaterians like placozoans. These small disc-shaped animals have only nine morphologically described cell types and no neurons, but show coordinated behaviors triggered by peptide-secreting cells. We investigated the possible neuronal affinities of these peptidergic cells using phylogenetics, chromatin profiling, and comparative single-cell genomics in four placozoans species. We found highly conserved cell type expression programs across placozoans, including populations of transdifferentiating and cycling cells suggestive of active cell type homeostasis. We also uncovered an unexpected diversity of fourteen peptidergic cell types that express neuronal-associated components like the presynaptic scaffold and that derive from progenitor cells with neurogenesis signatures. In contrast, earlier-branching animals like sponges and ctenophores lacked this conserved expression. Our findings indicate that key neuronal developmental and effector gene modules evolved before the advent of cnidarian/bilaterian neurons in the context of paracrine cell signalling.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Trichoplax Sp. H2 Hoilungia Hongkongensis

SUBMITTER: Eduard Sabidó

LAB HEAD: Eduard Sabido

PROVIDER: PXD042821 | Pride | 2023-11-10

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	2023LZ009-SBNA-TrH2.with_NP_annot-CON.fasta	Fasta
	2023LZ009_SBNA_001_01_10pto.raw	Raw
	2023LZ009_SBNA_001_02_45pto.raw	Raw
	2023LZ009_SBNA_3-injections-database-search-PD.xlsx	Xlsx
	2023LZ012-2023LZ009_SBNA_3-injections-deepnovo-PEAKS.xlsx	Xlsx

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Publications

Stepwise emergence of the neuronal gene expression program in early animal evolution.

Najle Sebastián R SR Grau-Bové Xavier X Elek Anamaria A Navarrete Cristina C Cianferoni Damiano D Chiva Cristina C Cañas-Armenteros Didac D Mallabiabarrena Arrate A Kamm Kai K Sabidó Eduard E Gruber-Vodicka Harald H Schierwater Bernd B Serrano Luis L Sebé-Pedrós Arnau A

Cell 20230919 21

The assembly of the neuronal and other major cell type programs occurred early in animal evolution. We can reconstruct this process by studying non-bilaterians like placozoans. These small disc-shaped animals not only have nine morphologically described cell types and no neurons but also show coordinated behaviors triggered by peptide-secreting cells. We investigated possible neuronal affinities of these peptidergic cells using phylogenetics, chromatin profiling, and comparative single-cell geno ...[more]

PMID: 37729907

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