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The role of the bursa in rotator cuff disease.

ABSTRACT: Rotator cuff injuries result in over 500,000 surgeries performed annually, an alarmingly high number of which fail. These procedures typically involve repair of the injured tendon and removal of the subacromial bursa. However, recent identification of a resident population of mesenchymal stem cells and inflammatory responsiveness of the bursa to tendinopathy indicate an unexplored biological role of the bursa in the context of rotator cuff disease. Therefore, we aimed to understand the clinical relevance of bursa-tendon crosstalk, characterize the biologic role of the bursa within the shoulder, and test the therapeutic potential for targeting the bursa. Proteomic profiling of patient bursa and tendon samples demonstrated that the bursa is activated by tendon injury.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Bursa Of Fabricius

SUBMITTER: Rajesh Soni

LAB HEAD: Stavros Thomopoulos

PROVIDER: PXD043481 | Pride | 2024-11-06

REPOSITORIES: pride

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	BM834.zip	Other
	BM834_Fusion_TMT_TotalProteome_Set_I_Set_II_RC.xlsx	Xlsx

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