Proteomics

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Discovering radiation biomarkers in plasma of total-body irradiated leukemia patients

ABSTRACT: The population's increasing risk of acute large-scale radiological/nuclear exposures underlines the need for functional radiation biomarkers. As ionizing radiation triggers a complex response on the genome, proteome, and metabolome level, all were already reported as suitable indicators of radiation-induced damage in vitro or in animal models. We aim to analyze the blood of total-body irradiated (TBI) leukaemia patients using a mass spectrometry approach and to identify and quantify plasma proteins before and after irradiation. Combining two independent mass spectrometry approaches we identified 15 plasma proteins differing in the blood of TBI patients before and after irradiation. The majority of proteins were associated with the inflammatory responce of the immune system and with metabolism of lipids. These candidate radiation biomarkers might have implications for practical biological dosimetry.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

SUBMITTER: Pavel Rehulka  

LAB HEAD: Ales Tichy

PROVIDER: PXD043516 | Pride | 2024-06-16

REPOSITORIES: Pride

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Discovering the Radiation Biomarkers in the Plasma of Total-Body Irradiated Leukemia Patients.

Gabriela Rydlova R   Vera Vozandychova V   Pavel Rehulka R   Helena Rehulkova R   Igor Sirak S   Marie Davidkova D   Marketa Markova M   Alena Myslivcova-Fucikova MF   Ales Tichy T  

Radiation research 20240501 5

The increased risk of acute large-scale radiological exposure for the world's population underlines the need for optimal radiation biomarkers. Ionizing radiation triggers a complex response by the genome, proteome, and metabolome, all of which have been reported as suitable indicators of radiation-induced damage in vivo. This study analyzed peripheral blood samples from total-body irradiation (TBI) leukemia patients through mass spectrometry (MS) to identify and quantify differentially regulated  ...[more]

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