Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Teratocarcinoma Cell, Germ Cell Cancer Cell
DISEASE(S): Teratoma,Germ Cell Cancer
SUBMITTER: Gereon Poschmann
LAB HEAD: Gereon Poschmann
PROVIDER: PXD043529 | Pride | 2024-11-15
REPOSITORIES: Pride
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Cancer letters 20240129
In germ cell tumors (GCT), a growing teratoma during chemotherapy with decreasing tumor markers was defined as 'growing teratoma syndrome' (GTS) by Logothetis et al. in 1982. So far, its pathogenesis and specific treatment options remain elusive. We aimed at updating the GTS definition based on molecular and epigenetic features as well as identifying circulating biomarkers. We selected 50 GTS patients for clinical characterization and subsequently 12 samples were molecularly analyzed. We further ...[more]