Proteomics

Dataset Information

0

Comparative Proteomic Analysis of Six Pairs of Hepatocellular Carcinoma Tissues and Adjacent Non-tumor Tissues


ABSTRACT: Applying 4D-label free method to detect differential proteins in cancer tissue and para-cancerous tissue in 6 patients with hepatocellular carcinoma.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Liver

SUBMITTER: Sun Linmao  

LAB HEAD: Yao Liu

PROVIDER: PXD043544 | Pride | 2024-07-03

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
EE029LQB1_N1_Slot2-21_1_540.d.zip Other
EE029LQB1_N2_Slot2-22_1_541.d.zip Other
EE029LQB1_N3_Slot2-23_1_542.d.zip Other
EE029LQB1_N4_Slot2-24_1_544.d.zip Other
EE029LQB1_N5_Slot2-25_1_545.d.zip Other
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Publications

Acetylation-dependent regulation of core spliceosome modulates hepatocellular carcinoma cassette exons and sensitivity to PARP inhibitors.

Sun Linmao L   Liu Yufeng Y   Guo Xinyu X   Cui Tianming T   Wu Chenghui C   Tao Jie J   Cheng Cheng C   Chu Qi Q   Ji Changyong C   Li Xianying X   Guo Hongrui H   Liang Shuhang S   Zhou Huanran H   Zhou Shuo S   Ma Kun K   Zhang Ning N   Wang Jiabei J   Liu Yao Y   Liu Lianxin L  

Nature communications 20240618 1


Despite the importance of spliceosome core components in cellular processes, their roles in cancer development, including hepatocellular carcinoma (HCC), remain poorly understood. In this study, we uncover a critical role for SmD2, a core component of the spliceosome machinery, in modulating DNA damage in HCC through its impact on BRCA1/FANC cassette exons and expression. Our findings reveal that SmD2 depletion sensitizes HCC cells to PARP inhibitors, expanding the potential therapeutic targets.  ...[more]

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