Comparative Proteomic Analysis of Six Pairs of Hepatocellular Carcinoma Tissues and Adjacent Non-tumor Tissues
Ontology highlight
ABSTRACT:
INSTRUMENT(S): timsTOF Pro
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Liver
SUBMITTER: 
Sun Linmao
LAB HEAD: Yao Liu
PROVIDER: PXD043544 | Pride | 2024-07-03
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| EE029LQB1_N1_Slot2-21_1_540.d.zip | Other | |||
| EE029LQB1_N2_Slot2-22_1_541.d.zip | Other | |||
| EE029LQB1_N3_Slot2-23_1_542.d.zip | Other | |||
| EE029LQB1_N4_Slot2-24_1_544.d.zip | Other | |||
| EE029LQB1_N5_Slot2-25_1_545.d.zip | Other |
Items per page: 5 1 - 5 of 15 |
Publications
Acetylation-dependent regulation of core spliceosome modulates hepatocellular carcinoma cassette exons and sensitivity to PARP inhibitors.
Sun Linmao L Liu Yufeng Y Guo Xinyu X Cui Tianming T Wu Chenghui C Tao Jie J Cheng Cheng C Chu Qi Q Ji Changyong C Li Xianying X Guo Hongrui H Liang Shuhang S Zhou Huanran H Zhou Shuo S Ma Kun K Zhang Ning N Wang Jiabei J Liu Yao Y Liu Lianxin L
Nature communications 20240618 1
Despite the importance of spliceosome core components in cellular processes, their roles in cancer development, including hepatocellular carcinoma (HCC), remain poorly understood. In this study, we uncover a critical role for SmD2, a core component of the spliceosome machinery, in modulating DNA damage in HCC through its impact on BRCA1/FANC cassette exons and expression. Our findings reveal that SmD2 depletion sensitizes HCC cells to PARP inhibitors, expanding the potential therapeutic targets. ...[more]
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